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Height, weight, body mass index (BMI), Replica Bags Wholesale lower limb muscle strength, and endurance fitness were measured by standard protocols.Results: Compared with the controls, index offspring had higher BMI (27.8 v 26.0 kg/m2, p=0.02), weaker lower limb muscles (127 v 135 kg, p=0.006), more knee pain (47% v 22%, pv 17.1 cm2, p=0.01). With the exception of BMI, these differences persisted in multivariate analysis. There was a non significant trend to higher Replica Designer handbags cartilage volume at tibial sites and increased ROA in the offspring in the total and subgroup analyses, Wholesale replica handbags but no difference in height and endurance fitness.: BMI, muscle strength, knee pain, and medial tibial bone area, but not cartilage volume, appear to play a role in the genetic regulation and development of knee osteoarthritis.Osteoarthritis is the most common form of arthritis and a leading cause of musculoskeletal disability in most developed countries.1 The knee is one of the most frequently affected joints, with a prevalence of 30% in people older than 65 years2 and high resultant disability.3 While its aetiology and pathogenesis remains relatively poorly understood, knee osteoarthritis has been strongly associated with several environmental factors including obesity,4 6 previous injury,7 and meniscectomy.8 In addition, a modest but significant genetic effect of radiographic osteoarthritis (ROA) of the knee has been reported in most studies.9 14 However, linkage studies in knee osteoarthritis have been disappointing.15 Candidate gene studies have also been inconclusive,15 and no information is available on the genetic mechanisms of knee osteoarthritis.Recently, we reported ecological data suggesting that variations in knee cartilage volume development in children may explain sex and site differences in the occurrence of knee osteoarthritis in later life.16 Recent data from both twin and sibling pair studies have also suggested that knee cartilage volume is highly heritable.14,17 This implies that cartilage development may be important in the pathogenesis of knee osteoarthritis in later life, similar to the known relation between peak bone mass and fracture risk.18 However, non cartilage factors may also be involved.

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Homogeneity of the treatment effect over men and women was established by testing for a sex by treatment interaction. Generalised estimating equation (GEE) models were also fitted to test the robustness of the GLMMs. In addition we carried out cluster level analyses.

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